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Research area:
Synthesis and study of reactivity of polyhedral boranes, carboranes, and metallacarboranes. Development of methods of introduction of functional groups to boron polyhedrons in order to prepare conjugates with different biomolecules (amino acids, nucleosides, carbohydrides, lipids, porphyrins, phthalocyanines). Search of application of compounds prepared in medicine for diagnostics of malignant tumours and for boron neutron capture therapy of cancer. Development of new methods for the synthesis of practically valuable metal-containing compounds used for molecular conductors, semiconductor and ceramic materials.
Grants:
1. Basic research program of the Presidium of the Russian Academy of Sciences “Development of methods of synthesis of chemical compounds and design of new materials”
Subprogram “Development of organic synthesis methodology and design of compounds with valuable applied properties” (Coordinator – academician Yu.N.Bubnov).
Project title: “Development of methods of synthesis of organic derivatives of anionic boron hydrides for introduction them into biomolecules for creation of boron neutron capture therapy agents”. (Principal investigator – V.I.Bregadze).
2. RFBR № 10-03-00698 “Di- and polyfunctional carborane ligands and metallacomplexes on their base” (Principal investigator – V.I.Bregadze) 2010-2012.
3. RFBR № 08-03-00463 “New approaches to synthesis of boron-containing amino acids on the base of polyhedral boron compounds (carboranes, metallacarboranes, and boranes)” (Principal investigator – I.B.Sivaev) 2008-2010.
4. RFBR № 09-03-00504 “Synthesis of novel oxonium derivatives of polyhedral boranes” (Principal investigator – A.A.Semioshkin) 2009-2011.
5. RFBR-DFG (Germany) № 10-03-91331 “Liposomes with boron-containing lipids for neutron capture therapy” (Principal investigator – I.B.Sivaev) 2010-2011.
6. RFBR- China № 08-03-92216 “Synthesis of carborane thiolate (selenolate) containing metal complexes and their potential as antitumor agents” (Principal investigator – V.I.Bregadze) 2009-2010.
7. RFBR-India № 10-03-92657 “Dichalcogenolate complexes of carboranes and metallocarboranes as structure determining ligands in coordination and supramolecular chemistry” (Principal investigator – V.I.Bregadze) 2010-2011.
Publications:
1. I.B.Sivaev, V.I.Bregadze, Polyhedral Boranes for Medical Applications: Current Status and Perspectives, Eur. J. Inorg. Chem., 2009, 1433-1450.
2. A.Semioshkin, Ju.Laskova, B.Wojtczak, A.Andrysiak, I.Godovikov, V.Bregadze, Z.Lesnikowski, Synthesis of closo-dodecaborate based nucleoside conjugates, J. Organomet. Chem., 2009, 694, 1375-1379.
3. V.I.Bregadze, I.B.Sivaev, I.A.Lobanova, R.A.Titeev, D.I.Brittal, M.A.Grin, A.F.Mironov, Conjugates of boron clusters with derivatives of natural chlorin and bacteriochlorin, Appl. Radiat. Isotopes, 2009, 67, S101-S104.
4. V.I.Bregadze, A.A.Semioshkin, Ju.N.Laskova, M.Ya.Berzina, I.A.Lobanova, I.B.Sivaev, M.A.Grin, R.A.Titeev, D.I.Brittal, O.V.Ulybina, A.V.Chestnova, A.A.Ignatova. A.V.Feofanov, A.F.Mironov, Novel types of boronated chlorine e6 conjugates via “click chemistry”, Appl. Organometal. Chem., 2009, 23, 370-374.
5. N.P.Kushwah, V.K.Jain, A.Wadawale, O.B.Zhidkova, Z.A.Starikova, V.I.Bregadze, Synthesis, spectroscopy and structures of palladium(II) and platinum(II) complexes containing mercapto-o-carborane, J. Organomet. Chem., 2009, 694, 4146-4151.
6. A.A.Semioshkin, Ju.N.Laskova, O.B.Zhidkova, I.A.Godovikov, Z.A.Starikova, V.I.Bregadze, D.Gabel, Synthesis and Structure of Novel Closo-Dodecaborate Based Glycerols, J. Organomet. Chem., 2010, 695, 370-374.
7. V.Bregadze, I.Sivaev, I.Lobanova, O.Kazheva, G.Alexandrov, A.Kravchenko, V.Starodub, L.Buravov, L.Titov, O.A.Dyachenko. Synthesis, structure and electrical conductivity of fulvalenium salts of cobalt bis(dicarbollide) anion and its derivatives, J. Chem. Sci., 2010, 122, 37-41.
8. Y.Li, Q.Jiang, Y.Li, H.Yan, V.I.Bregadze, Cobalt-Mediated B−H Activation and Cyclopentadienyl-Participated Diels−Alder Addition in the Reaction of a 16e CpCo Complex Containing an o-Carborane-1,2-dithiolato Ligand with HC≡C−C(O)Ph, Inorg. Chem., 2010, 49, 4-6.
9. M.Yu.Stogniy, I.B.Sivaev, P.V.Petrovskii and V.I.Bregadze, Synthesis of monosubstituted functional derivatives of ortho-carborane on the base of 1-mercapto-ortho-carborane: 1-HOOC(CH2)nS-1,2-C2B10H11 and [7-HOOC(CH2)nS-7,8-C2B9H11]- (n = 1÷4), Dalton Trans., 2010, 39, 1817–1822.
10. V.I.Bregadze, I.D.Kosenko, I.A.Lobanova, Z.A.Starikova, I.A.Godovikov, I.B.Sivaev, C-H Bond Activation of Arenes by [8,8’-μ-I-3,3’-Co(1,2-C2B9H10)2] in the Presence of Sterically Hindered Lewis Bases, Organometallics, 2010, 29, 5366-5372.