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Field of investigations:
- creation of superelectrophiles of a new generation
- development of new selective syntheses of fine chemicals from alkanes and cycloalkanes
- elaboration of one-pot syntheses of 1,3-dicarbonyl adamantanoids with the same or different functionalities
- development of new strategy for selective one-pot synthesis of bifunctional compounds from “monofunctional alkanes” (“alkane like reactions”)
- the nature of new active superelectrophilic systems and mechanistic studies on superelectrophilic alkane activation and functionalization
Grants:
1. Russian Foundation for Basic Research (Project N 09-03-00110)
“Alkylation and acylation of С-, N- and О- nucleophilic substrates under the action of non-traditional reagents, namely saturated hydrocarbons and their monofunctional derivatives, in the presence of superelectrophiles”
2. The RAS Presidium Fund (7 P)
"Alkane - like" reactions of monofunctional alkanes as a new way for one-pot selective syntheses of bifunctional aliphatic compounds“
List of main publications (2008-2010 гг.):
1. Irena Akhrem, Dzhul’etta Avetisyan, Lyudmila Afanas’eva, Sergei Vitt, Pavel Petrovskii, Alexander V. Orlinkov. The first one-pot amidation of alkanes cycloalkanes, Tetrahedron Letters, 2008, 49, 1399-1404.
2. Alexander Orlinkov, Nikolai Kagramanov, Pavel. Petrovskii, Irena Akhrem. The first "alkane-like" functionalization of n-alkyl acetates: a new method for one-pot selective syntheses of bifunctional aliphatic compounds with an acetate group, Tetrahedron Letters, 2010, 51, 259-263.
3. Irena Akhrem, Dzhul’etta Avetisyan, Lyudmila Afanas’eva, Nikolai Kagramanov, Pavel Petrovskii, Alexander Orlinkov. The first one-pot “alkane-like” reactions of carbonyl-containing adamantanes, Tetrahedron Letters, 2010, 51, 907-911.
4. Irena S. Akhrem, Dzhu’letta V. Avetis’yan, Nicolai D. Kagramanov, Pavel V. Petrovskii, Nadezhda E. Mysova. One-pot N-acylation and alkylation of o-nitroaniline by saturated hydrocarbons in the presence of carbon monoxide, Mendeleev Commun. 2010, 20, 5, 257-259.
Patents:
1. I. S. Akhrem, L. V. Afanas’eva, S. V. Vitt, N. D. Kagramanov, P. V. Petrovskii, A. V. Orlinkov, I. M. Churilova. New 1,3,5,7 – tetraalkyladamantanes. The method of the preparation of 1,3,5,7 – tetraalkyladamantanes and modification of mixtures of polyalkyladamantanes (RU 2409545, 2008)
2. I. S. Akhrem, D. V. Avetisyan, E. I. Gorunov, N. D. Kagramanov, P. V. Petrovskii. 1,3-dicarbonyl adamantanes and the method of their preparation (submit).